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KMID : 0829220050290020061
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Korean Journal of Oral and Maxillofacial Pathology
2005 Volume.29 No. 2 p.61 ~ p.66
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COX-2 Expression gradually increased during DMBA-induced Hamster Buccal Pouch Carcinogenesis
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Kim Jeong-Seok
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Abstract
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Cyclooxygenase-2 (COX-2) is an inducible enzyme that is not found in normal conditions, but is induced by a variety of pathophysiologic conditions of tissues by growth factors, inflammatory stimuli, oncogenes and tumor promoters. COX-2 is upregulated in a number of epithelial cancers, including in oral premalignant and malignant lesions. The mode of action of COX-2 in carcinogenesis may include mutiple mechanisms that may be acting at different stages of malignant disease. In this study, the expression of COX-2 protein was assessed quantitatively and qualitatively by immunohistochemistry during DMBA-induced hamster buccal pouch carcinogenesis. The immunoreactivity for COX-2 protein increased as the tissue passed from hyperplasia to dysplasia and SCC. The highest mean expression was SCC at 14 week. The differences between COX-2 expression in the normal and that the dysplastic and carcinomatous lesions was statistically significant. In addition, the mean values of COX-2 expression in the stromal cells increased gradually during malignant progression. The results suggest that increased COX-2 expression may be associated with the chemically induced carcinogenic progression of hamster buccal pouch model. The gradual increasing COX-2 expression detected during the progressive manner toward more malignant lesions shows that the COX-2 protein can have an important role in both the early and the later stages of multistep oral carcinogenesis.
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KEYWORD
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COX-2, DMBA, Hamster buccal pouch carcinogenesis
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